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Additionally, Latvia studies have indicated its regenerative actions, including the stimulation of blood vessel and nerve outgrowth, synthesis of collagen, elastin, and glycosaminoglycans, support for immune function and nervous system

In addition, the proinflammatory form of cells, called pyroptosis, was also strongly inhibited by melatonin 80,81 (Fig

Approval for animal experiments All experiments involving live vertebrates were approved by the North South University Committee on the Ethics of Animal Experiments (Protocol Number: 2022/OR-NSU/IACUC/0301)

Notably, emodin has progressed to ex vivo human validation using RA patient-derived primary synoviocytes, increasing its relevance to human pathology

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